Ononot — In a clinical trial comparing a new medication to a placebo,

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Inferential Statisticshard

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In a clinical trial comparing a new medication to a placebo, the treatment effect $\Delta$ is found to be $\hat{\Delta} = 0.5$ with $SE(\hat{\Delta}) = 0.2$ . If a researcher tests $H_0: \Delta = 0$ using the Wald statistic, but the likelihood surface for $\Delta$ is notably asymmetric due to the small sample size, which statement best characterizes the limitation of the Wald test?